Segmentation
Machine-learning-based segmentation of large-scale electron microscopy imagery.
My research focuses on understanding and improving how machine learning models organize complex information. My work spans interpretable vision-language learning, human-guided representation learning, and large-scale computational image analysis.

Learning fine-grained and disentangled visual evidence for complex language queries.
Modern vision-language models can associate images with complex textual descriptions, but it is often unclear which visual evidence supports each individual semantic concept in the text. My current research investigates how fine-grained semantic structure can be explicitly introduced into vision-language representations to make their predictions more localized, disentangled, and interpretable.
In particular, I study prototype-mediated approaches that organize visual evidence through learnable semantic prototypes. Rather than relying solely on direct text-to-image attention, the model learns intermediate prototype structures that connect language concepts with relevant image regions without requiring dense segmentation annotations.
How can a model distinguish visual evidence for different concepts within the same description?
Can semantic structure emerge from weak supervision without pixel-level annotations?
Can prototype representations improve interpretability while preserving general vision-language capabilities?
Ongoing research · Manuscript in preparation

KeySI: An Interaction Framework for Tuning Text Embeddings Based on Human Feedback
Pretrained text embeddings capture general semantic relationships, but their representation of similarity may not align with the concepts that matter to a particular user. KeySI investigates how users can directly guide the organization of a learned embedding space through lightweight semantic feedback.
Users define and refine groups of meaningful keywords, which are translated into document-level supervision through retrieval and semantic filtering. The resulting feedback is then used to adapt the underlying representation model, allowing users to iteratively inspect and reshape the learned semantic space.
IEEE Transactions on Visualization and Computer Graphics · IEEE VIS 2026

Collaboration with Thomas M. DeCarlo · Tulane University
Coral skeletal growth bands provide valuable records of long-term coral growth and environmental change, but manually identifying and analyzing these structures across large CT datasets is time-consuming and requires domain expertise.
In collaboration with Thomas M. DeCarlo at Tulane University, I am working on machine-learning methods for analyzing coral skeletal CT and micro-CT imagery within the CoralCT platform. The project explores deep-learning approaches for detecting coral growth bands while incorporating expert feedback into the analysis process.
An additional research question is how well these models generalize across coral species and imaging conditions, including the tradeoff between shared cross-species models and species-specific adaptation.
Ongoing research

Harvard University · Lichtman Laboratory
At the Lichtman Laboratory at Harvard University, I worked on computational methods for analyzing large-scale electron microscopy data of the developing mouse cerebellum across multiple developmental stages.
My work focused on building and applying computational image-analysis methods for processing large microscopy datasets, including U-Net-based segmentation, feature-based image alignment, stitching-error detection, and reconstruction of biological structures across serial electron microscopy images.
Machine-learning-based segmentation of large-scale electron microscopy imagery.
Image alignment, stitching, error detection, and serial-section reconstruction.
Computational analysis of neuronal structures across developmental stages.